The biggest shock wave of the NCAA men's basketball tournament was delivered by No. 15 Middle Tennessee, who shocked No. 2 Michigan State 90-81.

Reggie Upshaw scored 21 points to lead the 25-and-9 Blue Raiders.

It marks just the eighth time a No. 2 seed has been beaten by a 15-seed and the first since 2013.

The Blue Raiders, who never trailed in the game with the Spartans, will play on Sunday versus No. 10 Syracuse.